Percepción del impacto económico en pacientes con cáncer en un hospital de tercer nivel, La Paz - Bolivia: un estudio exploratorio cualitativo / Perception of the economic impact in patients diagnosed with cancer in a third level hospital, La Paz - Bolivia: a qualitative exploratory study

Los pacientes con cáncer experimentan además del impacto de la enfermedad, el impacto económico, y este es más evidente en los pacientes con escasos recursos económicos, los motivos son multifactoriales. OBJETIVO: describir la percepción sobre el impacto económico en los pacientes bolivianos con cáncer en el Hospital de Clínicas Universitario- La Paz. MÉTODOS: el diseño es cualitativo exploratorio, muestreo por bola de nieve, se realizaron entrevistas a profundidad dirigidas a pacientes con cáncer del hospital de Clínicas Universitario de La Paz- Bolivia entre diciembre de 2018 a febrero de 2019. RESULTADOS: se entrevistaron a 11 pacientes y 9 familiares. Se han identificado el impacto de los gastos en los pacientes con cáncer en las siguientes categorías: Ahorros y deudas, vivienda, trabajo, familia, tratamiento, esfera psicológica, gastos a futuro, y en el cuidado de otros enfermos en la casa. Las percepciones son variables, algunos pacientes muestran mayor preocupación por su economía que por su enfermedad, relatan además el cambio que significó en su económica recibir el diagnóstico de cáncer en distintas áreas. CONCLUSIÓN: se ha encontrado, en el presente trabajo, que la percepción del impacto económico para los pacientes con cáncer es multidimensional. Se ha evidenciado además, que el impacto depende del estadio de la enfermedad y del contexto social que vive el paciente, siendo este variable y dando como resultado necesidades de acompañamiento variable por parte de los equipos oncológicos

Cancer patients experience, is about disease´s and economic impact, and this impact is more evident in patients with limited economic resources in low-income countries, the reasons are multifactorial. OBJECTIVE: describe the perception of the economic impact on Bolivian patients with cancer at the Hospital de Clínicas Universitario-La Paz. METHODS: the design is qualitative and exploratory, sampling was by snowball, in-depth interviews were conducted at cancer patients at the Clínicas Universitario de La Paz hospital - Bolivia between December 2018 and February 2019. RESULTS: 11 patients and 9 family members were interviewed. The impact of expenses on cancer patients has been identified in the following categories: Savings and debts, housing, work, family, treatment, psychological sphere, future expenses, and caring for other patients at home. Perceptions are variable, some patients show more significant concern about their finances than about their illness, and they also report the change that receiving the diagnosis of cancer meant in their finances in different areas. CONCLUSION: in this investigation, the perception of economic impact on cancer patients is multidimensional. It has also been shown that the impact depends on the stage of the disease, and the social context in which the patient lives, this being variable and resulting in variable support needs from the oncology teams

Impact of IMADOKO, a Tool for Confirming the Current Status, in Decision-Making Support for Better Recuperation Places for Terminal Cancer Patients and Their Families

We devised IMADOKO as a tool to confirm the current status of terminal cancer patients and are using it in the home care team. In this study, we retrospectively investigated the actual state of end-of-life care to clarify the impact of IMADOKO on decision-making support for terminal cancer patients and their families. The subjects were 64patients (male/female, 38/26) before IMADOKO introduction, and 140 patients (male/female, 78/62) after the introduction, with an average age of 74 years in both cases and the primary lesions were the pancreas, lung, and the gastrointestinal tract. The rate of death at home increased significantly after the introduction of IMADOKO, compared to before. In the IMADOKO introduced group, IMADOKO was used in 108 patients and all their families. The use of IMADOKO for the patient was not related to the location of death, but it significantly improved communication between the patient and family, and between patient/patient's family and medical staff. It was shown that IMADOKO may be useful for decision-making support in choosing a better place of recuperation.

Nutritional profile of cancer patients treated at an outpatient oncology center in the south region of Brazil

To evaluate the nutritional profile of cancer patients treated at an oncology center in South Brazil.This is a descriptive, exploratory and sectional study that was developed in a process that involved 100 patients aged between 18 and 75 years old, suffering from cancer.The anthropometric variables studied were weight, height, Body Mass Index (BMI), arm circumference (AC), arm muscle circumference (AMC),triceps skinfold (TSF) and corrected arm muscle area (cAMA). For subjective nutritional assessment, we used the Patient-Generated Subjective Global Assessment (PG-SGA). Nearly half of the patients evaluated had a critical need for nutritional intervention. There was a statistically significant association between cAMA and marital status, age and gender; between AC and age, gender and staging; between AMC and staging; between BMI and marital status and age; and between TSF and marital status. Patients diagnosed with IV stage had the lowest values for nutritional variables. There was no significant association between nutritional status of patients obtained by the PG-SGA instrument and sociodemographic characteristics. Malnutrition should be diagnosed as soon as possible,aiming at early intervention and improving survival and quality of life. Therefore, early nutritional assessment in cancer patients is required, combining subjective and objective methods.

Espiritualidade nos cuidados paliativos de pacientes oncológicos / Spirituality in palliative care of oncological patients / Spiritualité dans les soins palliatifs des patients oncologiques / Espiritualidad en la atención paliativa del paciente oncológico

Resumo A espiritualidade como ferramenta aos cuidados paliativos de pacientes oncológicos vem sendo cada vez mais abordada no contexto acadêmico, como integrante da qualidade de vida. Este estudo analisa de que forma a espiritualidade pode influenciar positivamente no tratamento oncológico e em cuidados paliativos, e contribuir com a melhora da qualidade de vida destes pacientes. Foram selecionados 29 artigos nacionais que evidenciaram a espiritualidade como variável positiva no enfrentamento aos cuidados paliativos, tanto para paciente quanto familiares e equipe multidisciplinar. A espiritualidade é utilizada como ferramenta pela equipe de cuidados paliativos como auxiliadora na compreensão do impacto causado pelo diagnóstico e cuidado integral do paciente, possibilitando ao profissional psicólogo intervir sobre o paciente e sua rede. Ao paciente e sua família, a espiritualidade atua como estratégia de enfrentamento e conforto. Este estudo encontrou limitações acerca de pesquisas com pacientes infantis/adolescestes e sua família.

Abstract The spirituality as a tool in palliative healthcare of oncology patients, has been increasingly studied and approached in the academic context, as an integrant of life quality improvement. The present study aimed to analyze how spirituality can positively influence oncology treatment and palliative care and contribute to the quality of life improvement of these patients. Through this literature review and the inclusion criteria, there had been 29 articles selected. Spirituality is used as a tool by the CP team as an aid to understanding de impact caused by the diagnosis and full-time patient care, it enables the psychologist professional to assist and intervene fully about the patient and its network; on the patient and his family, the spirituality acts as a coping strategy, safety, and comfort. The present study has found limitations around the study in children, adolescents, and their network.

Resumé La spiritualité en tant qu'outil de soins palliatifs des patients atteints de cancer est de plus en plus abordée dans le contexte académique, dans le cadre de la qualité de vie. La présente étude visait à analyser comment la spiritualité peut influencer positivement le traitement du cancer et les soins palliatifs et contribuer à améliorer la qualité de vie de ces patients. Grâce à cette revue de la littérature, 29 articles ont été sélectionnés. La spiritualité est utilisée comme outil par l'équipe de soins palliatifs pour aider à comprendre l'impact provoqué par le diagnostic et la prise en charge globale du patient, permettant au psychologue professionnel d'intervenir sur le patient et son réseau; pour le patient et sa famille, la spiritualité agit comme une stratégie d'adaptation et de confort. La présente étude a révélé des limites concernant la recherche avec des patients enfants / adolescents et leur famille.

Resumen La espiritualidad como herramienta para los cuidados paliativos del paciente oncológico se ha abordado cada vez más en el contexto académico como parte de la calidad de vida. El presente estudio tuvo como objetivo analizar cómo la espiritualidad puede influir positivamente en el tratamiento del cáncer y los cuidados paliativos, así como contribuir a mejorar la calidad de vida de estos pacientes. Se seleccionaron 29 artículos brasileños que abordaron la espiritualidad como una variable positiva en el afrontamiento a los cuidados paliativos tanto para los pacientes como sus familias y el equipo multidisciplinario. La espiritualidad es utilizada por el equipo de cuidados paliativos como herramienta de ayuda en la comprensión del impacto que ocasiona el diagnóstico y la atención integral del paciente, permitiendo al psicólogo profesional intervenir sobre el paciente y su red. Para el paciente y su familia, la espiritualidad actúa como estrategia de afrontamiento y consuelo. El presente estudio encontró limitaciones con respecto a la investigación con pacientes niños/adolescentes y su familia.

Actual Usage of a Pamphlet for Families of Terminally Ill Patients With or Without Cancer at Home

Objective: The purposes of this study were to explore the actual usage of a pamphlet for families of terminally ill patients both with and without cancer at home. Methods: We sent a questionnaire to 2,000 home-visit nursing administrators and obtained answers from 430. This study included 224 pamphlet users. Results: The pamphlet was used with 95.1% of families of cancer patients and with 76.8% of families of non-cancer patients. Most pamphlet users were concerned with the following: degree of worry and anxiety of the family, and the family’s and the patient’s hope for an at home death (families of both cancer patients and non-cancer patients more than 84%). The pamphlet was given to about 60% of families of both cancer patients and non-cancer patients between last last week and last month of life. Administrators found it difficult to decide the appropriate timing to hand out the pamphlet to 59.6% of families of cancer patients and 69.7% of families of non-cancer patients. Conclusion: Pamphlet use may be improved by clarifying the appropriate timing to give out the pamphlet.

Interacción comunicativa en salud. Comprensión de conceptos mínimos en pacientes oncológicos que asisten al Centro Asistencial Barros Luco (CAB / Communicative interaction in health. Compression of minimal concepts in cancer patients attending the Barros Luco Healthcare Center (CABL)

El presente estudio se centra en la importancia que tiene la interacción comunicativa entre médico y paciente durante el tratamiento del cáncer. El peso de la interacción recae en la comunicación efectiva desarrollada en las prácticas lingüísticas dentro de la medicina clínica. Aquí se aborda la comunicación en salud y se explica el grado de comprensión que el paciente oncológico tiene en torno a cuatro conceptos elementales: cáncer, metástasis, tipos de tumores y tipos de terapia, los que se expresaron para ellos en tres tipos de definiciones: técnica, acomodada y coloquial. Para esto se aplicó una encuesta sociolingüística mixta a 50 pacientes en el Hospital Barros Luco, en donde se observó que más del 50% de los pacientes comprende toda la información cuando esta se explica de manera técnica y, más del 70% incluso 80% comprende toda la información cuando se explica de una manera acomodada a la valoración del contexto, situación e interlocutores. Los resultados también indican que los médicos, según los pacientes entrevistados, explican con un lenguaje de código cerrado y, en ocasiones, simplemente no entregan la información. Según los resultados se puede concluir que la información previa junto con la experiencia comunicativa, entendida como una práctica social, ayudan a construir y representar una nueva realidad sociolingüística que coopera para que los pacientes oncológicos logren entender la información verbal, así como también el nuevo contexto social en el que se encuentran.

The present study focuses on the importance of the communicative interaction between doctor and patient during cancer treat-ment. The weight of the interaction falls on the effective communication developed in linguistic practices within clinical medicine. Here, health communication is addressed, and the degree of understanding that the cancer patient has around four elementary concepts been explained: cancer, metastasis, types of tumors, and types of therapy, which were expressed for them in three types of definitions: technical, well-off and colloquial. For this, a mixed sociolinguistic survey was applied to 50 patients at the Barros Luco Hospital, where it was observed that more than 50% of patients understand all the information when it is explained tech-nically, and more than 70% even 80% understand all the information when it is explained in a way adapted to the assessment of the context, situation, and interlocutors. The results also indicate that the doctors, according to the patients interviewed, explain with a closed code language and sometimes, simply do not provide the information. According to the results, it can be concluded that the previous information together with the communicative experience, understood as a social practice, help to build and represent a new sociolinguistic reality that cooperates so that cancer patients can understand verbal information, as well as the new context social where they are.

Study of a tooth gel formulation for hygiene and oral sequelae management in irradiated patients

Cervical-facial radiotherapy causes innumerable sequelae, being systemic or restricted to the oral environment. Theoral mucosa of these patients is profoundly compromised by radiotherapeutic treatment with or without chemotherapy,presenting several complications. Dentifrices containing sodium lauryl sulfate cause damage, as they lead to drynessof the mucosa. The objective of this work was to develop a dentifrice capable of minimizing xerostomia related toa lower abrasive effect, which was intended for hygiene, prevention of caries, control of dental biofilm, and toothsensitivity in cancer patients. The qualitative composition and physicochemical characteristics of ten dentifrices wereanalyzed, which enabled the preparation of the proposed formulation (PF) that was analyzed periodically for 180days. The quantitative analysis of spreadability not only indicated favorable behavior of the PF in relation to thepackaging and storage conditions but also revealed the need to raise the propylene glycol concentration in the PF toavoid the occurrence of syneresis after 60 days. Furthermore, pH data showed that the PF is compatible with the pHof oral homeostasis thus avoiding the occurrence of dental demineralization. It is suggested that the PF has a singularcomposition and physicochemical quality to be used as a suitable dentifrice for patients undergoing anticancer therapy

The Effectiveness of Qur’an Recitation Therapy and Aromatherapy on Cancer Patients’ Stress Level in Abdul Wahab Sjahranie Hospital Samarinda, Indonesia

@#Introduction: Cancer is a disease that not only causes physical trauma but also affects mental health. Feelings of anxiety and fear of undergoing therapy can trigger stress that causes cancer to get worsened. Qur’an recitation therapy and aromatherapy are considered to have two positive effects that can reduce stress levels in patients. This study aims to determine the effectiveness of Qur’an recitation on reducing stress levels in cancer patients. Methods: This is a quasi-experimental research with one group of pre-test and post-test without control design on 50 cancer patients in the chemotherapy unit of Abdul Wahab Sjahranie Hospital. Interventions are in the form of three therapy sessions of Qur’an recitation and aromatherapy, 30 minutes for each session. Measurements were carried out 4 times, one pretest and three post-tests using questionnaires adapted from DASS. Data then were analyzed using the Friedman Test. Results: There is a decrease stress level in the four groups of measurement time intervals (p <0.0001; χ2 = 143.383> 7.815). These results indicate that Qur’an recitation therapy and aromatherapy may be effective in lowering cancer patients’ stress levels. Conclusion: Hospital is recommended to facilitate cancer patients to access complementary and alternative medicine such as Qur’an recitation therapy and aromatherapy.

Practical Abilities of Discharge Planning Nurses in Supporting Discharge of Terminal Cancer Patients

The aim of this study was to investigate the practical abilities of discharge planning nurses to support discharge of terminal cancer patients. A survey was mailed to 477 discharge planning nurses (DPNs) who were employed at 120 designated regional cancer centers in Japan. Responses from 198 (valid response rate 41.5%) DPNs were subjected to analysis. The median number of years of DPN experience of the subjects was 2.5 years, and 90.2% of them had more than 10 years of nursing experience. Among the discharge planning abilities, “To Coordinate Post-discharge Care Balance” was significantly higher in the group with more nursing experience and in the group with longer DPN experience; “To Estimate Post-discharge Care Balance” and “To Prepare for Transition from the Hospital to a Care Facility” was significantly higher in the group with longer DPN experience and in the group with more experience working in home and community care. But “To make an agreement with the patient and their families” was not significantly different for experienced DPNs. It was suggested that in order to improve the quality of discharge planning, it is necessary to create a system that allows staffing based on individual experience and sharing of knowledge and experience of veteran DPNs.

Efficacy and Safety of Subcutaneous Levetiracetam Injection for Terminally-ill Cancer Patients: A Case Report

Introduction: Antiepileptic drugs were occasionally administered to manage seizures in terminally-ill cancer patients. When enteral route is no longer feasible due to dysphagia or depressed level of consciousness, subcutaneous route could be an option. We reported three cases of terminally cancer patients who received subcutaneous levetiracetam (LEV) due to an inability to administer via intravenous route. Cases: The age of 3 cases was 83, 75, 82 years, respectively. In all cases, the prognosis prediction at the start of subcutaneous LEV was about 1 month. In all cases, the route of administration of LEV was changed from intravenous to subcutaneous. No exacerbation of convulsions, or injection site reaction was confirmed after subcutaneous LEV administration. Discussion: We believe that subcutaneous LEV administration may be one of the treatment options for seizures in patients with terminal cancer for whom intravenous administration of LEV is no longer feasible.

Introduction of electronic cancer patient registries

The article is devoted to the review of the most developed systems of registration and control of patients suffering from oncological diseases. The creation of registries is based on the public health needs of countries in monitoring, storing and analyzing national data on such serious chronic diseases as cancer. The world and national experience in creating data storage systems shows the need to unify the information collection, to consolidate sources, and to use high quality information technologies that make it possible to exchange, analyze, protect and store data. In European countries and the USA, registries have specialized websites and provide information on epidemiology, trends, forecasts, and survival rate. This information is public.

The influence of self-help group therapy towards quality of life of cancer patients in palliative care

Background: The therapy of cancer treatment for patient affects the significant of physic, psychology, and information and social, so that it needs to support the adequate care. The supporting for adequate care is the way to improve the quality life of patients. One of the cares that given is self-help group therapy (SHG), it is a group treatment to share about the experiences of each other for cancer patient. This research is conducted to know the influences of self-help group therapy towards the quality of life of cancer patients that have a palliative care.Methods: The research uses a quantitative approach with quasi-experimental method with pre-test and post-test with control group design. The sample of this research is 14 respondents in control group and 14 respondents in intervention group.Results: There was significant difference value of quality of life pre-test rather than post-test in the intervention group, p=0.033, and there was no significant difference in the control group before and after intervention, p=0.190. The comparison between post-test intervention and post-test control group showed that there was significant difference of quality of life value. P value in intervention group was 0.002, while p value for the control group was 0.221.Conclusions: There was influence by giving self-help group (SHG) therapy towards the quality of life of cancer patients that have palliative treatment. The patient can expand the social networking, to accept the information, get the emotional supporting from their own group.

Factors Related to Emotional Instability in Spouses of Cancer Patients Receiving Palliative Chemotherapy

Objective: To clarify factors related to emotional instability in spouses of cancer patients receiving palliative chemotherapy. Methods: Semi-structured interviews were conducted with spouses of cancer patients receiving palliative chemotherapy, and the obtained data were qualitatively and inductively analyzed. Results: Through analysis, 9 related factors were identified: “realizing the severity of the situation when receiving an explanation of the pathological condition”, “an unclear prognosis”, “fear of losing any treatments”, “being pressed for treatment-related decision-making”, “increased daily burdens by the care”, “collapse the visions of the family future”, “communication with medical professionals”,“candid dialogues with the patient”, and “relationships with others”. Conclusion: It may be important for nurses to help families of cancer patients realistically manage their situation without excessive confusion, even when they experience emotional instability, and spend meaningful time with patients as an outcome of treatment, with an understanding of these related factors on such emotional instability.

Financial Distress of Cancer Patients and the Families: Analysis of Individual Consultations Data through Text Mining

This study aimed to clarify financial issues of cancer patients and their families through consultation records. At four sites, 125 reports of individual consultations with regard to employment and finances through financial planner and certified social insurance labor consultant were analyzed using text mining. The mean age of participants was 54.0 ± 10.1 years, and 70 were female (56.0%). The most frequent five words and their co-occurring words were as follows: “month” (104 times; co-occurring words: “leave of absence” and “year”), “injury and sickness allowance” (93 times; co-occurring words: “receive” and “leave of absence”), “current” (72 times; co-occurring words: “receive” and “income”), “work” (68 times; co-occurring words: “contents” and “continue”), and “treatment” (62 times; co-occurring words: “living” and “income”). Our result indicated that participants felt anxious about finances and impact on their life associated with cancer treatment. In addition, cancer patients and their families received advice about timing, ways, and choice of return to work, resigning, and continuing to work, and use of public system including injury and sickness allowance that people can use during their leave of absence from consultants.

Effects of Emotional Intelligence and Nursing Working Environment on Nursing Performance of Nurses Caring for Cancer Patients in Small and Medium Hospitals: The Mediating Effect of Communication Competence

PURPOSE: The purpose of this study was to investigate whether the effects of emotional intelligence and working environment on nursing performance of nurses caring for cancer patients in small and medium hospitals were mediated by communication competence.METHODS: The data was collected between Aug. 1 and Aug. 30, 2018 from 240 nurses caring for cancer patients from 11 small and medium hospitals in B city. Variables included in this study were the Wong and Law Emotional Intelligence Scale (WLEIS), the Practice Environment Scale of Nursing Work Index (PES-NWI), the Global Interpersonal Communication Competence (GICC), and nursing performance. The collected data were analyzed by t-tests, ANOVA and Scheffe's test, Pearson's correlation coefficients, and 3 step multiple regression using SPSS/WIN 24.0 and the Sobel test.RESULTS: Communication competence, in the relationship between emotional intelligence and nursing working environment on nursing performance in nurses caring for cancer patients in small and medium hospitals, showed a partial mediating effect (Z=5.24, p < .001; Z=2.44, p=.001 respectively).CONCLUSION: The results of this study showed the effects of emotional intelligence and nursing working environment on nursing performance of nurses caring for cancer patients in small and medium hospitals were mediated by communication competence.

Palliative Care and Nutritional Support for Eating-related Distress in Patients with Advanced Cancer and Their Family Members

There is a lack of recognition regarding the negative impact of cancer cachexia on advanced cancer patients and their family members. Management of cancer cachexia should address not only patients’ physical problems, but also psychosocial burdens of both patients and their family members. Eating-related distress (ERD) is one of the most representative psychosocial burdens experienced during cancer. Summary points of palliative care and nutritional support for ERD experienced by patients and their family members are described as below. 1) Management strategies should address ERD experienced by patients and their family members. 2) If multimodal treatments reduce the negative impact of cachexia, ERD placed on patients and their family members might be alleviated. 3) The main causes of ERD experienced by patients and their family members are a lack of knowledge about cachexia, unsuccessful attempts to increase body weight, expected occurrence of the patient’s death, and conflicts over food between them. 4) Supportive, communicative, and educational interventions would alleviate ERD of patients and their family members. 5) Palliative care and nutritional support for ERD experienced by patients and their family members needs to be tailored to the severity of the patient’s cachexia, especially in cases of refractory cachexia. Since ERD can change during cancer, palliative care and nutritional support need to be tailored to each advanced cancer patient and their family.

Comparison of Home Palliative Care for Elderly Patients with Cancer between Age Groups : A Multicenter Study

Purpose: This study was performed to compare the characteristics of home palliative care for elderly patients with cancer between age groups. Methods: The clinical records of 1,032 patients with cancer who received home medical care from June to November 2013 were reviewed retrospectively. Patients were classified as non-elderly (<65 years old), young-old (65-74 years), old-old (75-84 years), or oldest-old (≥85 years), and these groups were compared with respect to demographic characteristics, patient/family problems, outcomes, and medical care and services provided. Results: There was a higher percentage of patients with no caregiver in the oldest-old group than in the other groups (18%, p=0.014), while the young-old and oldest-old groups had a higher percentage of problems related to caregiving such as caregiver burden or absence of a caregiver (32% and 33%, p=0.002, respectively). In addition, the percentage of patients who required visiting nurses and care was higher in the old-old group (86% and 30%, respectively) and oldest-old group (89% and 35%, respectively) compared with the other two groups. Conclusion: Problems related to caregiving, such as caregiver burden or absence of a caregiver, were greater in the old-old and oldest-old groups, and a higher percentage of patients required visiting nurses and care in those two groups.

Current State of Home Palliative Care and Factors Influencing Death at Home for Terminally Ill Cancer Patients Living in Single-person Households

Purpose: This study investigated the current state of medical care and palliative care provided at home and the factors influencing death at home for terminally ill cancer patients living in single-person households. Methods: We conducted a retrospective questionnaire study of 1032 cancer patients living in single-person households who received home palliative care from 17 specialized home care clinics and finished home care between June and November 2013. We compared patient background factors, outcomes, home care services, and medical care between these patients and others not living in single-person households to investigate factors influencing death at home. Results: Compared with patients not living in single-person households, the patients living in single-person households were older, had a better performance status at initiation of home palliative care, showed a lower preference for dying at home, and received more frequent social hospitalization. Among the subjects from single-person households, factors influencing death at home were a family preference for dying at home (odds ratio (OR)=14.0), poor performance status at initiation of home palliative care (OR=4.0), and no hospitalization during home palliative care (OR=16.6). Conclusion: We found that death at home for terminally ill cancer patients living in single-person households and receiving home medical care and palliative care was influenced by family preference, the performance status at initiation of home palliative care, and hospitalization during home palliative care.

Biomarkers as predictors of mortality in critically ill patients with solid tumors

ABSTRACT Biochemical markers produced by the affected organ or body in response to disease have gained high clinical value due to assess disease development and being excellent predictors of morbidity and mortality. The aim of this study is to analyze different biochemical markers in critically cancer patients and to determine which of them can be used as predictors of mortality. This is a prospective, cross-sectional study conducted at a University Hospital in Porto Alegre - RS. Screening was done to include patients in the study. Serum biochemical markers obtained in the first 24 hours of Intensive Care Unit hospitalization were analyzed. A second review of medical records occurred after three months objected to identify death or Unit discharged. A sample of 130 individuals was obtained (control group n = 65, study group n = 65). In the multivariate model, serum magnesium values ​​OR = 3.97 (1.17; 13.5), presence of neoplasia OR = 2.68 (95% CI 1.13; 6.37) and absence of sepsis OR = 0.31 (95% CI 0.12; 0.79) were robust predictors of mortality. The association of solid tumors, sepsis presence and alteration in serum magnesium levels resulted in an increased chance of mortality in critically ill patients.

Relationship between Quality of Life and Nutritional Status in Colorectal Cancer Patients Undergoing Chemotherapy

Introduction: Malnutrition is associated with poorer outcomes following treatment for colorectal cancer (CRC). This study evaluates the relationship between nutritional status using scored Patient Generated-Subjective Global Assessment (PG-SGA) with the validated European Organisation for Research and Treatment of Cancer questionnaire (EORTC-QLQ C30) which consists of five functional scales, three symptoms scales and one item of global health/quality of life (QOL). Methods: A total of 42 CRC patients at oncology outpatient clinics from two hospitals in Malaysia participated in the study from March 2011 to March 2012. The participants were classified as either well-nourished (PG-SGA A) or malnourished (PG-SGA B and C). Results: The majority of patients were Chinese, male, with a mean age of 57.1 ?± 9.8 years and had been diagnosed with stage 2 CRC. Well-nourished patients had statistically significantly better QOL scores on symptom scales: fatigue (p<0.001), nausea and vomiting (p<0.05), and pain (p<0.001) compared to malnourished patients. PG-SGA was strongly correlated with the main domains of the QOL: global health status (r = -0.395, p<0.05), fatigue (r = 0.816, p<0.001), nausea and vomiting (r = 0.730, p<0.001) and pain (r= 0.629, p<0.001). The better the nutritional status (lower total mean score of PG-SGA), the higher the QOL (high mean score of global health status). Conclusion: The scored PG-SGA is suitable for use as a nutrition assessment tool to identify malnutrition and it is associated with QOL among this population